Structure of PDB 6pw4 Chain A Binding Site BS02

Receptor Information
>6pw4 Chain A (length=696) Species: 3055 (Chlamydomonas reinhardtii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKPSDYGCQLHYKHARVKGTLITAAELGLVDKYRDLKRAGQDILTCDWPY
HYSSILYACYGNQYKILQMVEREFVGSTQELTAMHTTRCWVGKNSAMVAA
YQGHLETMLYIIDLDMQGKFTEDLFKQRDVMGKNAMMWAASQGHTDTIEV
LLVRSLYRLLPEDCADPLVLKTRWKLVSLLADLASHCRDYDPGCSRSFFQ
EVLASIKYDPVAVKLKDVHITVRTLQGVIVSAYRAGMNCMGVIMYCQSLL
QQARYFDDLVAQLTAWEVKLLDTCRNKQEVQAILAPTEDDPSEPVGYALA
TFDKAFLSHKFVQQIFTEKWDTMGVTDYTKSLFGVVWGGCSLVVAFAAWA
TICPLVVVARSFLSPVQDFMMRGKVIVDSRFPWHVPLYRWLLTQCALITF
TVLLSYLVFSFDPSDPVPASVAPLNTFLAVWCAAILVDEVQEYVEEGRAE
YMSSGWNVMDVTMALSYILHYILRIIAVRVTDNLNILLVVNDLLAAAALM
AWFRMVSVFELSSAIGPLIQMMKQMLIKDVTRFALLVLVILLGFSVGMEA
LFQERVTGVIFYLIFAIVTAILLLNLFIAMLADTYTRVSTQAMVEFRYRK
AKLMASYSRRDFVCPPFNLLHLVCAAVGNGLPVSMRKNETVPLFSWYFPQ
GEEMRQVVVLQRRVVDDFLNSNRVALFREKLNAELPNLVHEMLKQK
Ligand information
Ligand IDCPL
InChIInChI=1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1
InChIKeyJLPULHDHAOZNQI-ZTIMHPMXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(OCC(OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COP([O-])(=O)OCC[N+](C)(C)C)CCCCCCCCCCCCCCC
OpenEye OEToolkits 1.5.0CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341CCCCCCCCCCCCCCCC(=O)OC[CH](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCC=CCCCCC
CACTVS 3.341CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P]([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C/C=C\CCCCC
OpenEye OEToolkits 1.5.0CCCCCCCCCCCCCCCC(=O)OC[C@H](CO[P@@](=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC
FormulaC42 H80 N O8 P
Name1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;
PALMITOYL-LINOLEOYL PHOSPHATIDYLCHOLINE
ChEMBL
DrugBankDB02306
ZINC
PDB chain6pw4 Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pw4 Structure of the thermo-sensitive TRP channel TRP1 from the alga Chlamydomonas reinhardtii.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		Y85 Y87 Y95 W125 Y136
Binding residue
(residue number reindexed from 1)		Y50 Y52 Y60 W90 Y101
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pw4, PDBe:6pw4, PDBj:6pw4
PDBsum6pw4
PubMed31519888
UniProtQ0Z852

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