Structure of PDB 6p24 Chain A Binding Site BS02

Receptor Information

>6p24 Chain A (length=241) Species: 83333 (Escherichia coli K-12)

LAAETIDVSLPGRRIENGGLHPVTRTIDRIESFFGELGFTVATGPEIEDD
YHNFDALNIPGHHPARADHDTFWFDTTRLLRTQTSGVQIRTMKAQQPPIR
IIAPGRVYRNDYDQTHTPMFHQMEGLIVDTNISFTNLKGTLHDFLRNFFE
EDLQIRFRPSYFPFTEPSAEVDVMGKNGKWLEVLGCGMVHPNVLRNVGID
PEVYSGFAFGMGMERLTMLRYGVTDLRSFFENDLRFLKQFK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6p24 Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6p24 Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
• Resolution: 2.12 Å
• Binding residue (original residue number in PDB): E256 E268
• Binding residue (residue number reindexed from 1): E170 E182
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.20: phenylalanine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004826 phenylalanine-tRNA ligase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0006432 phenylalanyl-tRNA aminoacylation
• GO:0043039 tRNA aminoacylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0009328 phenylalanine-tRNA ligase complex

External links

• PDB: RCSB:6p24, PDBe:6p24, PDBj:6p24
• PDBsum: 6p24
• PubMed: 33411531
• UniProt: P08312|SYFA_ECOLI Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)