Structure of PDB 6p0c Chain A Binding Site BS02

Receptor Information
>6p0c Chain A (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMV
ETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVA
QATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFR
DIARLTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSV
LAALSQAVSLTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCE
VPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFE
EAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIK
LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYA
FDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAE
FLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDL
VVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHH
QSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAAR
GLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQS
Ligand information
Receptor-Ligand Complex Structure
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PDB6p0c Two-tiered enforcement of high-fidelity DNA ligation.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		S303 R549 R589 K744 K746 Y749 T798 G799 F800 S801 D802 F872 R874
Binding residue
(residue number reindexed from 1)		S44 R290 R330 K485 K487 Y490 T539 G540 F541 S542 D543 F613 R615
Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6p0c, PDBe:6p0c, PDBj:6p0c
PDBsum6p0c
PubMed31780661
UniProtP18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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