Structure of PDB 6ozf Chain A Binding Site BS02

Receptor Information

>6ozf Chain A (length=221) Species: 2336 (Thermotoga maritima)

MDYRQLHRWDLPPEEAIKVQNELRKKIKLTPYEGEPEYVAGVDLSFPGKE
EGLAVIVVLEYPSFKILEVVSERGEITFPYIPGLLAFREGPLFLKAWEKL
RTKPDVVVFNGQGLAHPRKLGIASHMGLFIEIPTIGVAKSRLYGTFKMPE
DKRCSWSYLYDGEEIIGCVIRTKEGSAPIFVSPGHLMDVESSKRLIKAFT
LPGRRIPEPTRLAHIYTQRLK

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6ozf Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ozf Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): D43 H214
• Binding residue (residue number reindexed from 1): D43 H214
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.21.7: deoxyribonuclease V.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003727 single-stranded RNA binding
• GO:0004519 endonuclease activity
• GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters
• GO:0043737 deoxyribonuclease V activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006281 DNA repair

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6ozf, PDBe:6ozf, PDBj:6ozf
• PDBsum: 6ozf
• PubMed: 31444105
• UniProt: Q9X2H9|NFI_THEMA Endonuclease V (Gene Name=nfi)