Structure of PDB 6ote Chain A Binding Site BS02

Receptor Information

>6ote Chain A (length=409) Species: 353152 (Cryptosporidium parvum Iowa II)

IDINRIRVEKGGDYQKIAESEMARYKGLETLEELVKVDQKWREDMFKLEQ
SKKESVQLKKNLPIIEKQALETEEVRDKLWHKIGNVLQPDVPISNTEDDN
LVLRTWGEIPDIKVDGTPGKLHHNEIMSRLGFYDSVKGAELAGHRGYFLK
DYGVIMSMALSHYAMGFLLKKGYLAIQPPYFMKRDLMGKAAELQDFEETL
YHIPSDNSKGEVDSNSLFLIATSEQPIAAMHHNVTLEDKDLPIKYAGIST
CFRKEAGAHGKDTWGIFRIHQFEKVEQFCVTLPEDSQKIHEEMISISEEF
YQSLELPYRVISIVSGALNDAASKKYDLEAWFPGYNSYRELVSCSNCTDY
QSRALECRLKHYCHFLNGTLCAIQRTMCCIVENYQTPDGLRIPKVLQPYM
NGVEFIPFK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6ote Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ote Crystal Structure of Seryl-tRNA synthetase (SerRS) from Cryptosporidium parvum complexed with L-Serylsulfamoyl Adenosine
• Resolution: 2.95 Å
• Binding residue (original residue number in PDB): E368 S371
• Binding residue (residue number reindexed from 1): E340 S343
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.1.1.11: serine--tRNA ligase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0000166 nucleotide binding
• GO:0004812 aminoacyl-tRNA ligase activity
• GO:0004828 serine-tRNA ligase activity
• GO:0005524 ATP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006418 tRNA aminoacylation for protein translation
• GO:0006434 seryl-tRNA aminoacylation

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:6ote, PDBe:6ote, PDBj:6ote
• PDBsum: 6ote
• UniProt: Q5CVB3