Structure of PDB 6omk Chain A Binding Site BS02

Receptor Information

>6omk Chain A (length=417) Species: 5664 (Leishmania major) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AHHHHHAHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIAS
TFEWWTPNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPP
NYIPDWHVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEA
AKYDEPRHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTA
GVLLPTPYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQ
LPSAPKNSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPR
DGVVFTYVVENVKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSI
PLHQLILDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGPGDGHLRYYFY
NWAYPKIKPSQVALVML

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6omk Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6omk Crystal structure of a glycylpeptide N-tetradecanoyltransferase (N-myristoyl transferase, NMT) from Leishmania major Friedlin bound to tetradecanoyl-CoA
Resolution	2.1 Å
Binding residue (original residue number in PDB)	H1 H3
Binding residue (residue number reindexed from 1)	H3 H5
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Gene Ontology

	Molecular Function
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
GO:0016746	acyltransferase activity

	Biological Process
GO:0006499	N-terminal protein myristoylation

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6omk, PDBe:6omk, PDBj:6omk
PDBsum	6omk
PubMed
UniProt	Q9GPZ4

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