Structure of PDB 6oeo Chain A Binding Site BS02

Receptor Information
>6oeo Chain A (length=608) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRAQKHRLRELKIQVKEFADKEEGGDVKAVCLTLFLLALRARNEHRQADE
LEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKAITGRQIFQPL
HALRNAEKVLLPGYHPFEWQPPLKNVSSRTDVGIIDGLSGLASSVDEYPV
DTIAKRFRYDSALVSALMDMEEDILEGMRSQDLDDYLNGPFTVVVKESCD
GMGDVSEKHGSGPAVPEKAVRFSFTVMRITIEHGSQNVKVFEEPKPNSEL
CCKPLCLMLADESDHETLTAILSPLIAEREAMKSSELTLEMGGIPRTFKF
IFRGTGYDEKLVREVEGLEASGSVYICTLCDTTRLEASQNLVFHSITRSH
AENLQRYEVWRSNPYHESVEELRDRVKGVSAKPFIETVPSIDALHCDIGN
AAEFYKIFQLEIGEVYKHPNASKEERKRWQATLDKHLRKRMNLKPIMRMN
GNFARKLMTQETVDAVCELIPSEERHEALRELMDLYLKMKPVWRSSCPAK
ECPESLCQYSFNSQRFAELLSTKFKYRYEGKITNYFHKTLAHVPEIIERD
GSIGAWASEGNQSGNKLFRRFRKMNARQSKCYEMEDVLKHHWLYTSKYLQ
KFMNAHNA
Ligand information
>6oeo Chain I (length=46) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gatctggcctgtcttacacagtgatacagcccttaacaaaaacccg
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6oeo Cutting antiparallel DNA strands in a single active site.
Resolution3.69 Å
Binding residue
(original residue number in PDB)		R440 A441 N443 D600 E709 H795 R848 N850 N852 K931 T933 N934 Y935 K966
Binding residue
(residue number reindexed from 1)		R40 A41 N43 D200 E309 H395 R448 N450 N452 K531 T533 N534 Y535 K566
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0002250 adaptive immune response
GO:0002331 pre-B cell allelic exclusion
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0008542 visual learning
GO:0030183 B cell differentiation
GO:0033077 T cell differentiation in thymus
GO:0033151 V(D)J recombination
GO:0043029 T cell homeostasis
GO:0045580 regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0048538 thymus development
GO:0051865 protein autoubiquitination
GO:0070233 negative regulation of T cell apoptotic process
GO:0070244 negative regulation of thymocyte apoptotic process
GO:2000822 regulation of behavioral fear response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6oeo, PDBe:6oeo, PDBj:6oeo
PDBsum6oeo
PubMed32015552
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

[Back to BioLiP]