Structure of PDB 6oeb Chain A Binding Site BS02

Receptor Information
>6oeb Chain A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSP
VLLSRLHFEKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDT
VMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKPEN
WEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRM
PAILDGEEAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNT
PECLAPV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6oeb Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		W81 R106 K109
Binding residue
(residue number reindexed from 1)		W80 R105 K108
Binding affinityPDBbind-CN: Kd=720nM
Enzymatic activity
Enzyme Commision number 3.4.-.-
4.-.-.-
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
Biological Process
GO:0006974 DNA damage response
GO:0106300 protein-DNA covalent cross-linking repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6oeb, PDBe:6oeb, PDBj:6oeb
PDBsum6oeb
PubMed31235913
UniProtQ96FZ2|HMCES_HUMAN Abasic site processing protein HMCES (Gene Name=HMCES)

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