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BioLiP

Structure of PDB 6o7i Chain A Binding Site BS02

Receptor Information
>6o7i Chain A (length=741) Species: 523850 (Thermococcus onnurineus NA1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIDELTALGGLLHDIGKPVQRAGLYDHSTQGARFLRDLAENTGRAEYELL
SLFSEFHHKGHMKNDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNL
ASGPLYSVFNPGKAYPWAELDFEKELPVPGDRSQDYRELVKRLWEELSKA
KLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRAGCT
AEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSGKGTLKYLRARSAYLEL
IGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAV
EWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEARKRLKHKLTVRKL
KRFGEIKGLFEHGHTERLAECPVCGRELPEGKLEPSASDPETKVCPTCNR
LVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQPVGEQILVKNTL
NPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMASTGTRRLGVMKGD
VDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGKFGYIIGDVPSL
RDWPEEPDIVVVYAGGDAFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLS
VGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVVGRSRPLSYEWNHY
EELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIRELYVRDPNDVRWAY
LTAYLLGRLVGIDTKAVERKEPQPVYWVDGVLKIVLMAVRR
Ligand information
Receptor-Ligand Complex Structure
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PDB6o7i Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		I243 I247 F290 G293 H295 D521 L525 G526 S542 M545 Y584 G587 D588 K648 R652
Binding residue
(residue number reindexed from 1)		I225 I229 F272 G275 H277 D500 L504 G505 S521 M524 Y563 G566 D567 K627 R631
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:6o7i, PDBe:6o7i, PDBj:6o7i
PDBsum6o7i
PubMed31326272
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

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