Structure of PDB 6o75 Chain A Binding Site BS02

Receptor Information
>6o75 Chain A (length=710) Species: 342948 (Thermococcus onnurineus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEY
ELLSLFSENDELMIRRIKELSPERFGLTMEDVLNALWIVYEADNLASPQA
SRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKRLWEEL
SKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRA
GCTAEDVRSGRCRKEKRFLLIEGDFSGIQDFIYRVSTLKYLRARSAYLEL
IGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAV
EWLYREFESDLYLAIEWEPVSGREFGREGGKNLFAEARKRLKHKLTVRKL
KRFGEIKGLFECNRLVSLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGG
RPVGEQILVKNTLNPGEIPESAQFVPYFVADYFKKDPKGGVATFEELSMA
STGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIE
GKFGYIIGDVPSLRDWPEEPDIVVVYAGGDAFFIVGAWDQIFELAFRVRR
AFNAYTGGKLTLSVGLGYFDERTPIYRMADVVSERLDTAKDEGRNRVFVV
GRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWK
LLEIRELYVRDPNDVRWAYLTLSDLFPELVGIDTKAVERKEPQPVYWVDG
VLKIVLMAVR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6o75 Second Messenger cA4Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D239 S241 G242 I243 Q244 I247 S263 L266 G293 Y584 A589 D645
Binding residue
(residue number reindexed from 1)		D224 S226 G227 I228 Q229 I232 S245 L248 G275 Y526 A531 D587
Enzymatic activity
Enzyme Commision number 2.7.7.-
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0042802 identical protein binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6o75, PDBe:6o75, PDBj:6o75
PDBsum6o75
PubMed31326272
UniProtB6YWB8|CAS10_THEON CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A) (Gene Name=csm1)

[Back to BioLiP]