Structure of PDB 6nfp Chain A Binding Site BS02

Receptor Information

>6nfp Chain A (length=292) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

KTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTVEDLGDIPI
NREKIDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIGTL
AGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVN
LEGYAPKIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKV
IEETLDYLSACDGVHLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEM
LYDAGIITSAEFVEVNPILDHKNKTGKTAVELVESLLGKKLL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6nfp Chain A Residue 307

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6nfp 1.7 Angstrom Resolution Crystal Structure of Arginase from Bacillus subtilis subsp. subtilis str. 168
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): H97 D120 D124 D223
• Binding residue (residue number reindexed from 1): H93 D116 D120 D219
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.3.1: arginase.

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0016787 hydrolase activity
• GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0000050 urea cycle
• GO:0006525 arginine metabolic process
• GO:0019547 arginine catabolic process to ornithine

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6nfp, PDBe:6nfp, PDBj:6nfp
• PDBsum: 6nfp
• UniProt: P39138|ARGI_BACSU Arginase (Gene Name=rocF)