Structure of PDB 6n6j Chain A Binding Site BS02

Receptor Information

>6n6j Chain A (length=195) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQ
PDELLDSMSDWCKEHHGKSGLTKAVKESTITLQQAEYEFLSFVRQQTPPG
LCPLAGNSVHEDKKFLDKYMPQFMKHLHYRIIDVSTVKELCRRWYPEEYE
FAPKKAASHRALDDISESIKELQFYRNNIFKKKIDEKKRKIIENG

Ligand information

>6n6j Chain C (length=2) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6n6j A dedicated diribonucleotidase resolves a key bottleneck for the terminal step of RNA degradation.
Resolution	1.317 Å
Binding residue (original residue number in PDB)	Y132 R133
Binding residue (residue number reindexed from 1)	Y129 R130

Enzymatic activity

Enzyme Commision number

3.1.15.-

Gene Ontology

	Molecular Function
GO:0000175	3'-5'-RNA exonuclease activity
GO:0003676	nucleic acid binding

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Molecular Function

External links

PDB	RCSB:6n6j, PDBe:6n6j, PDBj:6n6j
PDBsum	6n6j
PubMed	31225796
UniProt	Q9Y3B8\|ORN_HUMAN Oligoribonuclease, mitochondrial (Gene Name=REXO2)

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