Structure of PDB 6mu5 Chain A Binding Site BS02

Receptor Information
>6mu5 Chain A (length=578) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAFTLADRVTEEMLADKAALVVEVVEENYHDAPIVGIAVVNEHGRFFLRP
ETALADPQFVAWLGDETKKKSMFDSKRAAVALKWKGIELCGVSFDLLLAA
YLLDPAQGVDDVAAAAKMKQYEAVRPDEAVYGKGAKRAVPDEPVLAEHLV
RKAAAIWALERPFLDELRRNEQDRLLVELEQPLSSILAEMEFAGVKVDTK
RLEQMGEELAEQLRTVEQRIYELAGQEFNINSPKQLGVILFEKLQLPVLK
KTKTGYSTSADVLEKLAPYHEIVENILHYRQLGKLQSTYIEGLLKVVRPD
TKKVHTIFNQALTQTGRLSSTEPNLQNIPIRLEEGRKIRQAFVPSESDWL
IFAADYSQIELRVLAHIAEDDNLMEAFRRDLDIHTKTAMDIFQVSEDEVT
PNMRRQAKAVNFGIVYGISDYGLAQNLNISRKEAAEFIERYFESFPGVKR
YMENIVQEAKQKGYVTTLLHRRRYLPDITSRNFNVRSFAERMAMNTPIQG
SAADIIKKAMIDLNARLKEERLQARLLLQVHDELILEAPKEEMERLCRLV
PEVMEQAVTLRVPLKVDYHYGSTWYDAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6mu5 Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase.
Resolution1.912 Å
Binding residue
(original residue number in PDB)		N527 N529 S530 T586 L610 S617 T619 Y714 G715 I716 S717 Y719 N782 F786 R789
Binding residue
(residue number reindexed from 1)		N229 N231 S232 T288 L312 S319 T321 Y416 G417 I418 S419 Y421 N484 F488 R491
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0004518 nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006974 DNA damage response
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6mu5, PDBe:6mu5, PDBj:6mu5
PDBsum6mu5
PubMed31170294
UniProtE1C9K5

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