Structure of PDB 6m7u Chain A Binding Site BS02

Receptor Information
>6m7u Chain A (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSKLCPDLLLAQVRESRGKANLTKYREASVEVMEIMSRF
AVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLPQGVQK
EGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGFQCS
AGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLG
ASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPVKPR
QLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDNDRVA
TQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSGIQT
EWSPPLTMLFLCATKFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m7u Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		Q38 K40 I48 S62 K293 K317 T318 G320 C321 S322 K323 N324 R351
Binding residue
(residue number reindexed from 1)		Q39 K41 I49 S63 K280 K304 T305 G307 C308 S309 K310 N311 R338
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6m7u, PDBe:6m7u, PDBj:6m7u
PDBsum6m7u
PubMed30275308
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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