Structure of PDB 6m7t Chain A Binding Site BS02

Receptor Information
>6m7t Chain A (length=420) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIA
VSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEV
MEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEG
LPQEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERETGF
QCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGG
KLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHDPV
KPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRNDND
RVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNTSG
IQTEWSPPLTMLFLCATKFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m7t Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q38 I48 S62 K293 K317 T318 I319 G320 C321 S322 K323 N324 R351
Binding residue
(residue number reindexed from 1)		Q39 I49 S63 K283 K307 T308 I309 G310 C311 S312 K313 N314 R341
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6m7t, PDBe:6m7t, PDBj:6m7t
PDBsum6m7t
PubMed30275308
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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