Structure of PDB 6m7p Chain A Binding Site BS02

Receptor Information
>6m7p Chain A (length=428) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPETVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMR
AAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMP
IRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAM
CRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEER
LTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFT
VIKNCNTSTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m7p Bypassing a 8,5'-cyclo-2'-deoxyadenosine lesion by human DNA polymerase eta at atomic resolution.
Resolution1.75 Å
Binding residue
(original residue number in PDB)		E116 R256 S257 G259 G260 K261 L262 R377 R382 C384
Binding residue
(residue number reindexed from 1)		E119 R255 S256 G258 G259 K260 L261 R376 R381 C383
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6m7p, PDBe:6m7p, PDBj:6m7p
PDBsum6m7p
PubMed30275308
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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