Structure of PDB 6m0w Chain A Binding Site BS02

Receptor Information
>6m0w Chain A (length=1032) Species: 322159 (Streptococcus thermophilus LMD-9) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGSDLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTN
RQGRRLARRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDE
LSNEELFIALKNMVKHRGISYKTPGQIQLERYQTYGQLRGDFTVEKDGKK
HRLINVFPTSAYRSEALRILQTQQEFNPQITDEFINRYLEILTGKRKYYH
GPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFYPDEFRAAKASYTAQE
FNLLNDLNNLTVPTETKKLSKEQKNQIINYVKNEKAMGPAKLFKYIAKLL
DVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETLDKLAYVL
TLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSSIFGKGWHNFSV
KLMMELIPELYETSEEQMTILTRLGYIDEKLLTEEIYNPVVAKSVRQAIK
IVNAAIKEYGDFDNIVIEMARETNEDDEKKAIQKIQKANKDEKDAAMLKA
ANQYNGKAELPHSVFHGHKQLATKIRLWHQQGERCLYTGKTISIHDLINN
SNQFEVDAILPLSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDAW
SFRELKAFVRESKTLSNKKKEYLLTEEDISKFDVIERNLVDTRYASRVVL
NALQEHFRAHKIDTKVSVVRGQFTSQLRRHWGIEKTRDTYHHHAVDALII
AASSQLNLAPYQHFVDTLKSKEFEDSILFSYQVDSKFNRKISDATIYATR
QAKVGKDKADETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQT
FEKVIEPILENYPNKVPCNPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYD
SKLGNHIDITPKDSNNKVVLQSVSPWRADVYFNKTTGKYEILGLKYADLQ
FEKGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQ
QLFRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQCKKGL
GKSNISIYKVRTDVLGNQHIIKNEGDKPKLDF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m0w Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Resolution2.76 Å
Binding residue
(original residue number in PDB)		Y120 Y225 F252 L255 G257 R267 N286 R338 T383 W424 E445 M447 T448 T451 R512 E513 N515 K520 Q527 G558 K560 K565 E596 D598 A599 S604 N622 Q623 Q627 F673 R688 Y689 D824 A825 T826 Y828 M1049 Q1052 Y1055 A1080 N1081 S1082 K1087
Binding residue
(residue number reindexed from 1)		Y121 Y198 F225 L228 G230 R240 N259 R309 T354 W395 E416 M418 T419 T422 R471 E472 N474 K479 Q486 G517 K519 K524 E555 D557 A558 S563 N581 Q582 Q586 F632 R643 Y644 D743 A744 T745 Y747 M960 Q963 Y966 A991 N992 S993 K998
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6m0w, PDBe:6m0w, PDBj:6m0w
PDBsum6m0w
PubMed
UniProtQ03LF7|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

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