Structure of PDB 6m0v Chain A Binding Site BS02

Receptor Information
>6m0v Chain A (length=1030) Species: 322159 (Streptococcus thermophilus LMD-9) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGSDLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTN
RQGRRLARRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDE
LSNEELFIALKNMVKHRGISYKTPGQIQLERYQTYGQLRGDFTVEKDGKK
HRLINVFPTSAYRSEALRILQTQQEFNPQITDEFINRYLEILTGKRKYYH
GPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFYPDEFRAAKASYTAQE
FNLLNDLNNLTVPTETKKLSKEQKNQIINYVKNEKAMGPAKLFKYIAKLL
DVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETLDKLAYVL
TLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSSIFGKGWHNFSV
KLMMELIPELYETSEEQMTILTRLGYIDEKLLTEEIYNPVVAKSVRQAIK
IVNAAIKEYGDFDNIVIEMARETNEDDEKKAIQKIQKANKDEKDAAMLKA
ANQYNGKAELPHSVFHGHKQLATKIRLWHQQGERCLYTGKTISIHDLINN
SNQFEVDAILPLSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDAW
SFRELKAFVRESKTLSNKKKEYLLTEEDISKFDVIERNLVDTRYASRVVL
NALQEHFRAHKIDTKVSVVRGQFTSQLRRHWGIEKTRDTYHHHAVDALII
AASSQLNLYQHFVDTLKSKEFEDSILFSYQVDSKFNRKISDATIYATRQA
KVGKDKADETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQTFE
KVIEPILENYPNKVPCNPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDSK
LGNHIDITPKDSNNKVVLQSVSPWRADVYFNKTTGKYEILGLKYADLQFE
KGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQL
FRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQCKKGLGK
SNISIYKVRTDVLGNQHIIKNEGDKPKLDF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m0v Catalytic-state structure and engineering of Streptococcus thermophilus Cas9
Resolution3.0 Å
Binding residue
(original residue number in PDB)		Y120 Y225 F252 L255 G257 R267 N286 T383 W424 E445 T448 R512 E513 K520 I523 G558 K560 E596 D598 S604 N622 Q623 F673 R688 Y689 R692 D824 A825 T826 Y828 M1049 Q1052 Y1055 A1080 N1081 Q1084 K1087
Binding residue
(residue number reindexed from 1)		Y121 Y198 F225 L228 G230 R240 N259 T354 W395 E416 T419 R471 E472 K479 I482 G517 K519 E555 D557 S563 N581 Q582 F632 R643 Y644 R647 D741 A742 T743 Y745 M958 Q961 Y964 A989 N990 Q993 K996
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6m0v, PDBe:6m0v, PDBj:6m0v
PDBsum6m0v
PubMed
UniProtQ03LF7|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

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