Structure of PDB 6m00 Chain A Binding Site BS02

Receptor Information
>6m00 Chain A (length=294) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTEKLMKAGEIAKKVREKAIKLARPGMLLLELAESIEKMIMELGGKPAFP
VNLSINEIAAHYTPYKGDTTVLKEGDYLKIDVGVHIDGFIADTAVTVRVG
MEEDELMEAAKEALNAAISVARAGVEIKELGKAIENEIRKRGFKPIVNLS
GHKIERYKLHAGISIPNIYRPHDNYVLKEGDVFAIEPFATIGAGQVIEVP
PTLIYMYVRDVPVRVAQARFLLAKIKREYGTLPFAYRWLQNDMPEGQLKL
ALKTLEKAGAIYGYPVLKEIRNGIVAQFEHTIIVEKDSVIVTTE
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain6m00 Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6m00 crystal structure of Methionine aminopeptidase from Pyrococcus furiosus
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D93 H153 E187 E280
Binding residue
(residue number reindexed from 1)		D92 H152 E186 E279
Annotation score3
Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m00, PDBe:6m00, PDBj:6m00
PDBsum6m00
PubMed
UniProtP56218|MAP2_PYRFU Methionine aminopeptidase (Gene Name=map)

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