Structure of PDB 6lym Chain A Binding Site BS02

Receptor Information
>6lym Chain A (length=1281) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFADLNAPL
NDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKATDIAHN
CGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSSLTDAE
KLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQEAFTKL
GRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIKNTFET
TPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMKVETHN
HPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQ
PWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTYEEKVN
SHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGPAMNIG
LDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNAMPE
LVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFD
ELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPKMTR
DVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGARTVTGMV
ARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAASARL
AVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVGEEL
CPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDVRHT
LTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVAQLK
GFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAALGD
DHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDRF
VITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKANDTD
PGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFHRAG
FDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSILFNH
RVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVRNHSDR
FEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAALES
KGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHPERV
FRTVANSWHPENWGEDSPWMRIFRNARKQLG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6lym Chain A Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6lym Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase.
Resolution2.46 Å
Binding residue
(original residue number in PDB)		D679 N722 D884
Binding residue
(residue number reindexed from 1)		D665 N708 D870
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.5.3: phosphoribosylformylglycinamidine synthase.
Gene Ontology
Molecular Function
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lym, PDBe:6lym, PDBj:6lym
PDBsum6lym
PubMed
UniProtP74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)

[Back to BioLiP]