Structure of PDB 6lyk Chain A Binding Site BS02

Receptor Information
>6lyk Chain A (length=1293) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASGLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHF
ADLNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSK
ATDIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVF
SSLTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYL
QEAFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKM
IKNTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHIL
MKVETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNL
RIPGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFR
TYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLG
GPAMNIGLGGGDLDFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHD
VGAGGLSNAMPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYV
LAVAADQLPLFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPL
DVLLGKTPKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFL
VTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAP
VALLDFAASARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAG
LYDAVKAVGEELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVI
SAFARVEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGD
KPADVRDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGH
CGVQVDIAALGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCV
HYLGQALAGDRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCA
DQEHEAKANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNS
HVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGA
GEGWAKSILFNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSE
LWPRFVRNHSDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVE
VRDDAHLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENG
RVTIMMPHPEAVFRTVANSWHPENWGEDSPWMRIFRNARKQLG
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain6lyk Chain A Residue 1618 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6lyk Mechanism of Coordinated Gating and Signal Transduction in Purine Biosynthetic Enzyme Formylglycinamidine Synthetase.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		G1092 G1093 F1094 D1098 C1135 N1136 Q1139 S1195 H1196 G1197 E1198 H1260
Binding residue
(residue number reindexed from 1)		G1090 G1091 F1092 D1096 C1133 N1134 Q1137 S1193 H1194 G1195 E1196 H1258
Annotation score5
Enzymatic activity
Enzyme Commision number 6.3.5.3: phosphoribosylformylglycinamidine synthase.
Gene Ontology
Molecular Function
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lyk, PDBe:6lyk, PDBj:6lyk
PDBsum6lyk
PubMed
UniProtP74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)

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