Structure of PDB 6lxk Chain A Binding Site BS02

Receptor Information

>6lxk Chain A (length=387) Species: 11320 (Influenza A virus)

VKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTF
FLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSAS
ACHDGINWLTIGISGPDSGAVAVLKYNGIITDTIKSWRNNILRTQESECA
CVNGSCFTIMTDGPSDGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCY
PDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGVFGDNPRPNDKT
GSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRKGFEMIWDPNGWTG
TDNKFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPE
ENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTIDK

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6lxk Chain A Residue 502

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6lxk Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus.
• Resolution: 3.608 Å
• Binding residue (original residue number in PDB): D376 N378 D384 K386
• Binding residue (residue number reindexed from 1): D294 N296 D302 K304
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0020002 host cell plasma membrane
• GO:0033644 host cell membrane
• GO:0044423 virion component
• GO:0055036 virion membrane

External links

• PDB: RCSB:6lxk, PDBe:6lxk, PDBj:6lxk
• PDBsum: 6lxk
• PubMed: 33024040
• UniProt: A0A5P1N996