Structure of PDB 6lwb Chain A Binding Site BS02
Receptor Information
>6lwb Chain A (length=265) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
GQGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QPDLLELCHSVPKEVVQLGGRGYGEEDFAAFRAWLRCYGMPGMSSLQDRH
GRTIWFQGDPGPLAP
Ligand information
>6lwb Chain C (length=13) [
Search DNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
tagacctggacgg
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
6lwb
DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.
Resolution
2.55 Å
Binding residue
(original residue number in PDB)
R34 R95 H96 I117 R118 R119 F120
Binding residue
(residue number reindexed from 1)
R33 R94 H95 I116 R117 R118 F119
Enzymatic activity
Enzyme Commision number
3.2.2.-
4.2.99.18
: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676
nucleic acid binding
GO:0003684
damaged DNA binding
GO:0003906
DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270
zinc ion binding
GO:0016799
hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104
DNA N-glycosylase activity
Biological Process
GO:0006284
base-excision repair
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:6lwb
,
PDBe:6lwb
,
PDBj:6lwb
PDBsum
6lwb
PubMed
34226550
UniProt
Q96FI4
|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)
[
Back to BioLiP
]