Structure of PDB 6lkx Chain A Binding Site BS02

Receptor Information
>6lkx Chain A (length=441) Species: 28344 (Porcine reproductive and respiratory syndrome virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSRMCGYCGAPAPYATACGLDVCVYHTHFHQHCPVIIWCGHPAGSGSCSE
CEPPLGKGTSPLDEVLEQVPYKPPRTVIMHVEQGLTPLDPGRYQTRRGLV
SVRRGIRGNEVDLPDGDYASTALLPTCKEINMVAVASNVLRSRFIIGPPG
AGKTHWLLQQVQDGDVIYTPTHQTMLDMIRALGTCRFNVPAGTTLQFPAP
SRTGPWVRILAGGWCPGKNSFLDEAAYCNHLDVLRLLSKTTLTCLGDFKQ
LHPVGFDSHCYVFDIMPQTQLKTIWRFGQNICDAIQPDYRDKLMSMVNTT
RVTHVEKPVRYGQVLTPYHRDREDGAITIDSSQGATFDVVTLHLPTKDSL
NRQRALVAITRARHAIFVYDPHRQLQSMFDLPAKGTPVNLAVHRDEQLIV
LDRNNREITVAQALGNGDKFRATDKRVVDSLRAICADLELE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6lkx Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6lkx Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus.
Resolution2.998 Å
Binding residue
(original residue number in PDB)		C41 H43 C50 C53
Binding residue
(residue number reindexed from 1)		C39 H41 C48 C51
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N140 M177 V394 Q399 L400
Catalytic site (residue number reindexed from 1) N138 M175 V392 Q397 L398
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:6lkx, PDBe:6lkx, PDBj:6lkx
PDBsum6lkx
PubMed32461315
UniProtD2CSC7

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