Structure of PDB 6l8n Chain A Binding Site BS02

Receptor Information
>6l8n Chain A (length=810) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RWSRYIGSIHTMGFATRPTVKPVPIGSRLGFKKSSHLVRLIDTSQDRELG
RMPEDVARILYPLLDYSEQVSLEPYLLINNGKRFSVGDNIYIRIDCYLTS
QAFVMDTRQLHRAGAIMALFDAINIQPVYALNINQLKSFYRITQSAASLQ
NLPETTPDESLFKLQLRRYQKQSLSWMLKREYEYSHLSEKMNPLWKKFRW
PSNSDCFFYANLYTGEFSIEKPVIKTIINGGILADEMGLGKTISALALIC
TASYDEAHEKKIESTDTYAYRTTLIVVPMSLLNQWQSEFEKANKDLKKRC
EIYYGNNIKDLRAYVLGPNAPSVIITTYGIIQSEYGRTSTSGLFNVVFFR
IILDEGHTIRNRSTRTSKAVIALRSSRKWILTGTPIINRLDDLFSLVQFL
NLEPWSHINYWKRYVSVPFEKGNYAQAFDVINAVLEPVLLRRTKNMKDVD
GKPLVSLPPKEVIVEKLQLSSSEKRVYQSMLEDAENSVKEGLAKGDLLKN
YTNILVHILRLRQVCCHLDLLKPKSSISQDKLDALSANFRDIHSASEQLP
SFECAICTTECIEPLSAVSITECLHTFCEPCLAEYIEFQQNKKLSINCPY
CRMPISEANVLKLKEPIDAERGYELISFHSHFQSTKIKALLRHLKQIQET
SPGEQIIVFSQFSSFLDILEIELRSHLPRDQVIIYKFDGRLDMKERTRIL
EQFHDKDLSCIKLLLLSLKTGGVGLNLTCASRAFMMDPWWSPGMEDQAID
RIHRIGQQQTVKVVRFIIDNSVEEKMLRIQERKRMLGDIVEGDEAERRQK
RIEEIQMLFQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6l8n Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6l8n Structural basis for the multi-activity factor Rad5 in replication stress tolerance.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		H879 C902 C905
Binding residue
(residue number reindexed from 1)		H575 C598 C601
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0046872 metal ion binding
GO:0140658 ATP-dependent chromatin remodeler activity

View graph for
Molecular Function
External links
PDB RCSB:6l8n, PDBe:6l8n, PDBj:6l8n
PDBsum6l8n
PubMed33436623
UniProtQ6CJM4|RAD5_KLULA DNA repair protein RAD5 (Gene Name=RAD5)

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