Structure of PDB 6l7v Chain A Binding Site BS02

Receptor Information
>6l7v Chain A (length=180) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAEQRAVAKALFDAVNKHLSNPFIEVEMRLGQFKANFTACVSTEDYERIK
TYLMTEMENSSMTRSVTHDVWRHTYATDENGNPTRCVSIVRKKRLFVKNI
VVPLGAYNLRFAVSTETPTRLKDRLSITDGMFRYDMTQVTEKGVLMHEVE
IEGVFSSKQLTESWLEELLRRAMRLATLRT
Ligand information
Ligand ID3PO
InChIInChI=1S/H5O10P3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h(H,7,8)(H2,1,2,3)(H2,4,5,6)
InChIKeyUNXRWKVEANCORM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O
OpenEye OEToolkits 1.5.0OP(=O)(O)OP(=O)(O)OP(=O)(O)O
ACDLabs 10.04O=P(OP(=O)(O)OP(=O)(O)O)(O)O
FormulaH5 O10 P3
NameTRIPHOSPHATE
ChEMBLCHEMBL1230191
DrugBankDB03896
ZINCZINC000006827739
PDB chain6l7v Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6l7v Crystal structures of the RNA triphosphatase fromTrypanosoma cruziprovide insights into how it recognizes the 5'-end of the RNA substrate.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E42 R46 R118 K138 E162 K182 R184
Binding residue
(residue number reindexed from 1)		E25 R29 R72 K92 E116 K122 R124
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0004651 polynucleotide 5'-phosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:6l7v, PDBe:6l7v, PDBj:6l7v
PDBsum6l7v
PubMed32381506
UniProtQ4E2I1

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