Structure of PDB 6kwr Chain A Binding Site BS02

Receptor Information
>6kwr Chain A (length=453) Species: 39054 (Enterovirus A71) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDIFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLHEPDEYIKEAALHYANQLKQLEINTSQMSMEEA
CYGTENLEAIDLHTSAGYPYSALGIKKRDILDPTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMAFGHLYEAFHA
NPGTITGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPVNWGNATFLKRGFLPDEQFPFLIHPTMPMREIHESIRWTKDAR
NTQDHVRSLCLLAWHNGKQEYEKFVSTIRSVPVGRALAIPNYENLRRNWL
ELF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kwr A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y327 D329 L375 R377 S401 K406 N410 S417
Binding residue
(residue number reindexed from 1)		Y327 D329 L366 R368 S392 K397 N401 S408
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6kwr, PDBe:6kwr, PDBj:6kwr
PDBsum6kwr
PubMed31863580
UniProtM4QLY4

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