Structure of PDB 6kwq Chain A Binding Site BS02

Receptor Information
>6kwq Chain A (length=462) Species: 39054 (Enterovirus A71) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWVKPNKETGRLNINGPTRTKLEPSVFHDIFEGNKEPAVLHSKDPRL
EVDFEQALFSKYVGNTLHEPDEYIKEAALHYANQLKQLEINTSQMSMEEA
CYGTENLEAIDLHTSAGYPYSALGIKKRDILDPTTRDVSKMKFYMDKYGL
DLPYSTYVKDELRSIDKIKKGKSRLIEASSLNDSVYLRMAFGHLYEAFHA
NPGTITGSAVGCNPDTFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
LVLREIGYSEEAVSLIEGINHTHHVYRNKTYCVLGGMPSGCSGTSIFNSM
INNIIIRALLIKTFKGIDLDELNMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPADKSPCFNEVNWGNATFLKRGFLPDEQFPFLIHPTMPMREIHE
SIRWTKDARNTQDHVRSLCLLAWHNGKQEYEKFVSTIRSVPVGRALAIPN
YENLRRNWLELF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kwq A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		H113 R128 Y327 G328 D330 L375 K376 S401 K406 N410 D413 H414 S417
Binding residue
(residue number reindexed from 1)		H113 R128 Y327 G328 D330 L375 K376 S401 K406 N410 D413 H414 S417
Binding affinityPDBbind-CN: Kd=0.18uM
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:6kwq, PDBe:6kwq, PDBj:6kwq
PDBsum6kwq
PubMed31863580
UniProtM4QLY4

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