Structure of PDB 6klh Chain A Binding Site BS02

Receptor Information
>6klh Chain A (length=1884) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DEYVQELKGLIRKHIPERCEFGHQKVTFLSQVHPSPLLTEGFKLLSSLVE
LESCEAHACQANTDQRFVDVILSDNGILCPTLPKVIPDGFKLTGKTLILL
ETFVRVNPDEFEKKWKADMSKLLNLKHDLQKSGVTLVPIVDGRSNYNNRF
VADWVIERIRWLLIEILKASKSEDQEYQRLIHSLSNVKLENLEHLKRNSL
DYDERLNESLFIGLKGDIRESTVREELIKLKLWFKDEVFSKGLGKFKLTD
RRELLESLSSLGAHLDSDVSSCPFCNNKLMEIVYNVTFSCVERSNIEKHY
LSVLSLCNKIKGLKVFNTRRNTLLFLDLIMVNLMVDISDSCQDAIESLRK
SGLIVGQMVMLVNDRVLDILEAVKLIRKKIGTNPNWVKNCSKILERSHPE
IWHHLSTLIKQPDFNSLISIAQHLVSDRPIMRYSKICRHKLFQEMSSFEQ
MRLFKTLSSISLSLINSMKTSFSSRLLVNEFGNVRLRECYAQRFYLAESL
VGFLFYQKTGERSRCYSVYLSDNGVMSEQGSFYCDPKRFFLPVFSDEVLA
GMCEEMTSWLDFDTGLMNDTGPILRLLVLAILCSPSKRNQTFLQGLRYFL
MAFANQIHHIDLTSKLVVECKSSSEVVVQRLAVGLFIRLLSGESDASLFF
SRRFKYLLNVSYLCHLITKETPDRLTDQIKCFEKFIEPKVKFGCAVVNPS
LNGKLTVDQEDIMINGLKKFFSKSLRDTEDVQTPGVCKELLNYCVSLFNR
GKLKVSGELKNNPFRIPKLDELGNILSTYDKEKLVSACVSSMAERFKNLD
PDSTDYLILKNLTLTEEQVESFNEIKHDVQVALAKMADVSLHEVKDFDPD
VLPPEVYKELCDAVYKSSEKCNFFLEGVLDVCPLGLLLKNLTTSSYVDEE
YFMCFKYLLIQGHFDQFTNAALRNLCFYSEDSPTEFTSISSNSGNLKFGL
SYKEQVGSNRELYVGDLNTKLMTRLVEDFSEAVGNSMKYTCLNSEKEFER
AICDMKMAVNNGDLSCSYDHSKWGPTMSPALFLALLQMLELRTPVDRSKI
DLDSVKSILKWHLHKVVEVPINVAEAYCIGSTSLSEEFFHQTMQLNGQIP
SHIMSVLDMGQGILHNTSDLYGLITEQFLCYALDLLYDVIPVSYTSSDDQ
ITLIKTPSDAAEWLEMICFHEFLSSKLNKFVSPKSVIGTFVAEFKSRFFV
MGEETPLLTKFVAAALHNVKCKTPTQLSETIDTICDQCIANGVSTKIVTR
ISKRVNQLIRYSGYGETPFGAIEDQDVKDWVDGSRGYRLQRKIEAIFHDD
KETSFIRNCARKVFNDIKRGRIFEENLINLIGRGGDEALTGFLQYAGCSE
QEVNRVLNYRWVNLSSFGDLRLVLRTKLMTVPTLIKTLQSKLSRQSSVAS
GFIGFCKSMGSKCVRDGGFLYIKEVYSGVSACTCEICALKPKIIYCNNSL
NKVSQFSKPILWDYFSLVLTNACELGEWVFSTVKEPQNNQNFFWAVKPKV
VRQIEDQLGMNHVLQSIRRNYPVLFDEHLTPFMNDLQVSRTMDSGRLKFL
DVCIALDMMNENLGIISHLLKTRDNSVYIVKQSDCALAHIRQSSYTDWEL
GLSPQQICTNFKTQLVLSSMVNPLVLSTSCLKSFFWFNEVLELEDDSQIE
LAELTDFALMVKNQNVSRAMFVEDIAMGYVVSNFEGVRISLSDHVRMSTK
FKLKRKMVYSFSLECIMDVGEIQNKEVILKVVAVDQSVSGSGGNHMLLDG
VSVVASLPLFTGQASFDLAAMLIESNLAGSNDSPELSDKYSYRLSGPENQ
EDPLVLKDGAFYVGGERLSTYKVEFTGDLVVKALGALEDDESVVSMLHQL
WPYLKATSQVILFQQEDFTIVHDLYKKQLTKSIE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6klh Chain A Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6klh Structural insight into arenavirus replication machinery.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		D1188 D1330 E1381
Binding residue
(residue number reindexed from 1)		D1019 D1149 E1193
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6klh, PDBe:6klh, PDBj:6klh
PDBsum6klh
PubMed32214249
UniProtQ6IVU0

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