Structure of PDB 6kda Chain A Binding Site BS02

Receptor Information
>6kda Chain A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHE
GNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKGLYEGTG
RLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPV
MIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLK
KVQTITTKSNSIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVS
NMGRGARQKLLGRSWSVPVIRHLFAPLKDYFACE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kda Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B.
Resolution2.909 Å
Binding residue
(original residue number in PDB)		S649 C651 N652 S655 V657 R733 Q772 T773 T776 K777 K785 G831 R832
Binding residue
(residue number reindexed from 1)		S80 C82 N83 S86 V88 R164 Q203 T204 T207 K208 K216 G262 R263
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6kda, PDBe:6kda, PDBj:6kda
PDBsum6kda
PubMed32083663
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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