Structure of PDB 6kc8 Chain A Binding Site BS02

Receptor Information
>6kc8 Chain A (length=1036) Species: 604162 (Neisseria meningitidis 8013) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SINYILGLDIGIASVGWAMVEIDEEENPIRLIDLGVRVFERAEVPGDSLA
MARRLARSVRRLTRRRAHRLLRTRRLLKREGVLQAANFDENGLIKSLPNT
PWQLRAAALDRKLTPLEWSAVLLHLIKHRGYLSQRKNETGDFRTPAELAL
NKFEKESGHIRNQRSDYSHTFSRKDLQAELILLFEKQKEFGNPHVSGGLK
EGIETLLMTQRPALSGDAVQKMLGHCTFEPAEPKAAKNTYTAERFIWLTK
LNNLRILEQGSERPLTDTERATLMDEPYRKSKLTYAQARKLLGLEDTAFF
KGLRYGKDNAEASTLMEMKAYHAISRALEKEGLKDKKSPLNLSPELQDEI
GTAFSLFKTDEDITGRLKDRIQPEILEALLKHISFDKFVQISLKALRRIV
PLMEQGKRYDEACAEIYGDHYGKKNTEEKIYLPPIPADEIRNPVVLRALS
QARKVINGVVRRYGSPARIHIETAREVGKSFKDRKEIEKRQEENRKDREK
AAAKFREYFSKDILKLRLYEQQHGKCLYSGKEINLGRLNEKGYVEIDHAL
PFSRTWDDSFNNKVLVLGSENQNKGNQTPYEYFNGKDNSREWQEFKARVE
TSRFPRSKKQRILLQDGFKERNLNDTRYVNRFLCQFVADRMRLTGKGKKR
VFASNGQITNLLRGFWGLRKVRAENDRHHALDAVVVACSTVAMQQKITRF
VRYKEMNAFDGKTIDTGEVLHQKTHFPQPWEFFAQEVMIRVFGKPDGKPE
FEEADTLEKLRTLLAEKLSSRPEAVHEYVTPLFVSRAPNRKMSGQGHMET
VKSAKRLDEGVSVLRVPLTQLKLKDLEKMVNREREPKLYEALKARLEAHK
DDPAKAFAEPFYKYDKAGNRTQQVKAVRVEQVQKTGVWVRNHNGIADNAT
MVRVDVFEKGDKYYLVPIYSWQVAKGILPDRAVVQGKDEEDWQLIDDSFN
FKFSLHPNDLVEVITKKARMFGYFASCHRGTGNINIRIHDLDHKIGKNGI
LEGIGVKTALSFQKYQIDELGKEIRPCRLKKRPPVR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6kc8 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y140 R144 L246 M254 L255 G256 K266 N285 K333 K390 D418 K419 F420 R440 D442 H452 Y453 R473 A506 R507 E508 R516 K517 Q523 R671 Y672 R675 G691 K692 A736 Q739
Binding residue
(residue number reindexed from 1)		Y131 R135 L214 M222 L223 G224 K234 N253 K301 K358 D386 K387 F388 R408 D410 H420 Y421 R441 A474 R475 E476 R484 K485 Q491 R627 Y628 R631 G647 K648 A692 Q695
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6kc8, PDBe:6kc8, PDBj:6kc8
PDBsum6kc8
PubMed31668930
UniProtC9X1G5|CAS9_NEIM8 CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

[Back to BioLiP]