Structure of PDB 6kc6 Chain A Binding Site BS02

Receptor Information
>6kc6 Chain A (length=197) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNC
RVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPGGGCRVIE
QKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEV
EELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6kc6 Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6kc6 Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Resolution2.123 Å
Binding residue
(original residue number in PDB)		C898 C901 H926 C930
Binding residue
(residue number reindexed from 1)		C32 C35 H60 C64
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6kc6, PDBe:6kc6, PDBj:6kc6
PDBsum6kc6
PubMed32246052
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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