Structure of PDB 6k1e Chain A Binding Site BS02

Receptor Information
>6k1e Chain A (length=196) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLESPLSLLQMASP
SGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDY
GLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLLRCSNWDAET
LTEDQVIYAARDAQISVALFLHLLGYSSWRKVLEKCQGVVDIPFRS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6k1e Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6k1e The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y242 D246
Binding residue
(residue number reindexed from 1)		Y158 D162
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
3.1.13.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6k1e, PDBe:6k1e, PDBj:6k1e
PDBsum6k1e
PubMed31127291
UniProtQ9NVH0|EXD2_HUMAN Exonuclease 3'-5' domain-containing protein 2 (Gene Name=EXD2)

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