Structure of PDB 6ju5 Chain A Binding Site BS02

Receptor Information
>6ju5 Chain A (length=542) Species: 5062 (Aspergillus oryzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPYLITGIPKDPKHPLPIRKDIDDWYLEQTSAGSNRIQLTLFVEALTVIQ
NRPLNDQLSYFRLAGIHGAPWTEWDGVPGTGFAVHNNYTFPTWHRVYVTL
YEQVIYEAMLDFIKQNVPQNGKADWENEAKQWRLPYWDFARFARDELRLP
ILVTMPMVKVLVPGQPGKQLSKPNPLYRFQMQTLMGTLERPYAITSFDLP
FDKCQSTTKYGLLENYNADVWADGGQNWLRANLALNEHPWYQNLDGWDSV
PTLQDMTFRLLTTGGLNWGEFSSTRYDDAPKNWMNLEAIHNNVHNWVGGF
MFSRPGRHDLKLWGAGHMSSVPVAAYDPIFWLHHCNIDRLTAIWQTVNSG
SWFNDDKSKVSKDDDLRPFHRFCEKTRKVVFFRSDDVKDWRSLNYDYAIT
KDASRIRKEISDLYGEDYILSIRYSRYALGGKPFQINIFFGDVDGKDFYD
ARSQNFVGSVFNYSGAQQEQEGVLSVSQLPARLAVHYYKKQNKGEVPTPR
YVVVNSQGKAEAEVKVEVALHKTDYRRVADGKRAEVDDAYRA
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain6ju5 Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ju5 Copper-Oxygen Dynamics in the Tyrosinase Mechanism.
Resolution1.34 Å
Binding residue
(original residue number in PDB)		H328 H332 H372
Binding residue
(residue number reindexed from 1)		H290 H294 H334
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0004503 tyrosinase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ju5, PDBe:6ju5, PDBj:6ju5
PDBsum6ju5
PubMed32356371
UniProtA0A1S9DK56

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