Structure of PDB 6jfm Chain A Binding Site BS02

Receptor Information

>6jfm Chain A (length=419) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQ
VLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSDVINAMLWDKVLPS
GITNCFLRVEGTDGHEAFLLTEGSEEKRSAKTVNQLAHALHQDKQLHAGS
LVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVA
NSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQH
MERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPELAEGF
QVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHM
AAREQQVYCEEMREERQDRTRENLEQEIAAMNKKIEVLDSLQSKAKLLRN
KAGWLDSELNMFTHQYLQP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

6jfm Chain A Residue 904 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6jfm Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset.
Resolution	2.09 Å
Binding residue (original residue number in PDB)	E73 D77
Binding residue (residue number reindexed from 1)	E49 D53
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.6.5.-

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

	Biological Process
GO:0008053	mitochondrial fusion

	Cellular Component
GO:0005741	mitochondrial outer membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6jfm, PDBe:6jfm, PDBj:6jfm
PDBsum	6jfm
PubMed	31664033
UniProt	O95140\|MFN2_HUMAN Mitofusin-2 (Gene Name=MFN2)

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