Structure of PDB 6j23 Chain A Binding Site BS02

Receptor Information

>6j23 Chain A (length=338) Species: 3702 (Arabidopsis thaliana)

MEWIQSLPKIELHAHLNGSIRDSTLLELARVLGEKGVIVFADVEHVIQKN
DRSLVEVFKLFDLIHKLTTDHKTVTRITREVVEDFALENVVYLELRTTPK
RSDSIGMSKRSYMEAVIQGLRSVSEVDIDFVRKKIYVRLLLSIDRRETTE
SAMETVKLALEMRDVGVVGIDLSGNPLVGEWSTFLPALQYAKDNDLHITL
HCGEVPNPKEIQAMLDFKPHRIGHACFFKDEDWTKLKSFRIPVEICLTSN
IVTKSISSIDIHHFADLYNAKHPLILCTNDFGVFSTSLSNEYALAVRSLG
LSKSETFALARAAIDATFAEDEVKQQLRFIFDSASPEH

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6j23 Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6j23 Structure ofArabidopsis thaliana N6-methyl-AMP deaminase ADAL with bound GMP and IMP and implications forN6-methyl-AMP recognition and processing.
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): H13 H15 H217 N295
• Binding residue (residue number reindexed from 1): H13 H15 H201 N279
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.5.4.-

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0019239 deaminase activity
• GO:0046872 metal ion binding
• GO:0062154 N6-methyl-AMP deaminase activity

Biological Process

• GO:0006401 RNA catabolic process
• GO:0009117 nucleotide metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6j23, PDBe:6j23, PDBj:6j23
• PDBsum: 6j23
• PubMed: 31318636
• UniProt: Q8LPL7|ADAL_ARATH N6-mAMP deaminase (Gene Name=MAPDA)