Structure of PDB 6imn Chain A Binding Site BS02

Receptor Information

>6imn Chain A (length=411) Species: 10497 (African swine fever virus)

MLNQFPGQYSNNIFCFPPIESETKSGKKASWIICVQVVQHNTIIPITDEM
FSTDVKDAVAEIFTKFFVEEGAVRISKMTRVTEGKNLGKKNATTVVHQAF
KDALSKYNRHARQKRGNRGMIPPMLVKYFNIIPKTFFEEETDPIVQRKRN
GVRAVACQQGDGCILLYSRTEKEFLGLDNIKKELKQLYLFIDVRVYLDGE
LYLHRKPLQWIAGQANAKTDSSELHFYVFDCFWSDQLQMPSNKRQQLLTN
IFKQKEDLTFIHQVENFSVKNVDEALRLKAQFIKEGYEGAIVRNANGPYE
PGYNNYHSAHLAKLKPLLDAEFILVDYTQGKKGKDLGAILWVCELPNKKR
FVVTPKHLTYADRYALFQKLTPALFKKHLYGKELTVEYAELSPKTGIPLQ
ARAVGFREPIN

Ligand information

>6imn Chain G (length=22)

tccgggatgcgtgtcggactgg

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6imn Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): S25 K27 V68 G71 A72 K85 N86 K89 S105 V155 S171 T173 L211 N219 K359 H360 T362 Y363 Q403 R405
• Binding residue (residue number reindexed from 1): S25 K27 V68 G71 A72 K85 N86 K89 S105 V152 S168 T170 L208 N216 K356 H357 T359 Y360 Q400 R402

Enzymatic activity

• Enzyme Commision number: 6.5.1.1: DNA ligase (ATP).

Gene Ontology

Molecular Function

• GO:0003909 DNA ligase activity
• GO:0003910 DNA ligase (ATP) activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006281 DNA repair
• GO:0006310 DNA recombination
• GO:0051301 cell division

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:6imn, PDBe:6imn, PDBj:6imn
• PDBsum: 6imn
• PubMed: 30674878
• UniProt: P35970|DNLI_ASFB7 DNA ligase (Gene Name=LIG)