Structure of PDB 6iae Chain A Binding Site BS02

Receptor Information

>6iae Chain A (length=155) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DDLVKILVLGPSKSGKSTVTNFLAGTRDETNPLRVLEVEIALKAVVQLWD
VGGSWPAIASNADGIIYVFNPEVKGSEKELLLWYKNFAMRVTDGHSLIFS
HHSSLPEFAVGDNAIPPMPKQLQGIRALETSLDYQSDNFKEAFDALVEQI
IASRL

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6iae Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6iae Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly.
Resolution	2.49 Å
Binding residue (original residue number in PDB)	S19 T39
Binding residue (residue number reindexed from 1)	S17 T30
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003924	GTPase activity
GO:0005525	GTP binding

	Biological Process
GO:0006886	intracellular protein transport
GO:0060271	cilium assembly

	Cellular Component
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005929	cilium
GO:0012505	endomembrane system
GO:0030992	intraciliary transport particle B
GO:0031514	motile cilium
GO:0036064	ciliary basal body

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6iae, PDBe:6iae, PDBj:6iae
PDBsum	6iae
PubMed	30940671
UniProt	Q381A3\|IFT22_TRYB2 Intraflagellar transport protein 22 (Gene Name=IFT22)

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