Structure of PDB 6i1l Chain A Binding Site BS02

Receptor Information
>6i1l Chain A (length=1277) Species: 401614 (Francisella tularensis subsp. novicida U112) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NASIYQEFVNKYSLSKTLRFELIPQGKTLENIKARGLILDDEKRAKDYKK
AKQIIDKYHQFFIEEILSSVCISEDLLQNYSDVYFKLKKSDDDNLQKDFK
SAKDTIKKQISEYIKDSEKFKNLFNQNLIDAKKGQESDLILWLKQSKDNG
IELFKANSDITDIDEALEIIKSFKGWTTYFKGFHENRKNVYSSNDIPTSI
IYRIVDDNLPKFLENKAKYESLKDKAPEAINYEQIKKDLAEELTFDIDYK
TSEVNQRVFSLDEVFEIANFNNYLNQSGITKFNTIIGGKFVNGENTKRKG
INEYINLYSQQINDKTLKKYKMSVLFKQILSDTESKSFVIDKLEDDSDVV
TTMQSFYEQIAAFKTVEEKSIKETLSLLFDDLKAQKLDLSKIYFKNDKSL
TDLSQQVFDDYSVIGTAVLEYITQQIAPKNLDNPSKKEQELIAKKTEKAK
YLSLETIKLALEEFNKHRDIDKQCRFEEILANFAAIPMIFDEIAQNKDNL
AQISIKYQNQGKKDLLQASAEDDVKAIKDLLDQTNNLLHKLKIFHISQSE
ILDKDEHFYLVFEECYFELANIVPLYNKIRNYITQKPYSDEKFKLNFENS
TLANGWDKNKEPDNTAILFIKDDKYYLGVMNKKNNKIFDDKAIKENKGEG
YKKIVYKLLPGANKMLPKVFFSAKSIKFYNPSEDILRIRNHSTHTKNGSP
QKGYEKFEFNIEDCRKFIDFYKQSISKHPEWKDFGFRFSDTQRYNSIDEF
YREVENQGYKLTFENISESYIDSVVNQGKLYLFQIYNKDFSAYSKGRPNL
HTLYWKALFDERNLQDVVYKLNGEAELFYRKQSIPKKITHPAKEAIANKN
KKESVFEYDLIKDKRFTEDKFFFHCPITINFKSSGANKFNDEINLLLKEK
ANDVHILSIDRGERHLAYYTLVDGKGNIIKQDTFNIIGNDRMKTNYHDKL
AAIEKDRDSARKDWKKINNIKEMKEGYLSQVVHEIAKLVIEYNAIVVFQD
LRGRFKVEKQVYQKLEKMLIEKLNYLVFKDNEFDKTGGVLRAYQLTAPFE
TFKKMGKQTGIIYYVPAGFTSKICPVTGFVNQLYPKYESVSKSQEFFSKF
DKICYNLDKGYFEFSFDYKNFGDKAAKGKWTIASFGSRLINFRWDTREVY
PTKELEKLLKDYSIEYGHGECIKAAICGESDKKFFAKLTSVLNTILQMRN
SKTGTELDYLISPVADVNGNFFDSRQAPKNMPQDADANGAYHIGLKGLML
LGRIKNNKKLNLVIKNEEYFEFVQNRN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6i1l Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Resolution2.98 Å
Binding residue
(original residue number in PDB)		N188 P196 G286 K296 E302 N305 K317 K320 S334 K397 T400 Q404 Y410 N584 Q588 K589 G826 E827 R964 K978 R1014 K1026 T1063
Binding residue
(residue number reindexed from 1)		N189 P197 G287 K297 E303 N306 K318 K321 S335 K398 T401 Q405 Y411 N581 Q585 K586 G823 E824 R957 K971 R1002 K1014 T1051
Enzymatic activity
Enzyme Commision number 3.1.21.1: deoxyribonuclease I.
4.6.1.22: Bacillus subtilis ribonuclease.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0016829 lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6i1l, PDBe:6i1l, PDBj:6i1l
PDBsum6i1l
PubMed30639240
UniProtA0Q7Q2|CS12A_FRATN CRISPR-associated endonuclease Cas12a (Gene Name=cas12a)

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