Structure of PDB 6hv8 Chain A Binding Site BS02

Receptor Information
>6hv8 Chain A (length=774) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMIRKQAESYANSTWEVLQYKDSGEPGVLEVFVTINGKVQNITFHIPKTI
YMKFKSQTMPLQKIKNCLIEKSSASLPNNPKTSNPESVFLEEKENCTSIF
NDENVLGVFEGTITPHQRAIMLSMAENERYLSGFSMDIGYLLHFPTSIGY
EFFSLFKSWGDTITILVLKPSNQAQEINASSLGQIYKQMFEKKKGKIETY
SYLVDIKEDINFEFVYFTDISKLYRRLSQETTKLKEERGLQFLLLLQSPF
ITKLLGTIRLLNQMPIVKLSLNEVLLPQLNWQPTLLKKLVNHVLSSGSWI
SHLIKLSQYSNIPICNLRLDSMDYIIDVLYARKLKKENIVLWWNEKAPLP
DHGGIQNWIMNDSEFPKINNSGVYDNVVLDVGVDNLTVNTILTSSNDALN
VLRGMLKEWWDEALKENSTADLLVNSLASWVQNPNAKLFDGLLRYHVHNL
TKKALLQLVNEFSALGSTIVYADRNQILIKTNKYSPENCYAYSQYMMKAV
RTNPMFSYLDLNIKRYWDLLIWMDKFNFSGLACIEIEEKENQDYTAVSQW
QLKKFLSPIYQPEFEDWMMIILDSMLKTKQSYLKLNKEDSVENSLNGFSH
LFSKPLMKRVKKLFKNQQEFILDPQYEASHLNVKNPLLELVKSLCHVMLL
SKSTILEISLVVPDFLCEYCFFISDIDFCKFSCVRCHKAFNQVLLQEHLI
QKLRSDIESYLIQDLRCSRCHKVKRDYMSAHCPCAGAWEGTLPRESIVQK
LNVFKQVAKYYGFDILLSCIADLT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6hv8 Chain A Residue 2302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hv8 Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		C2164 R2166 C2167
Binding residue
(residue number reindexed from 1)		C717 R719 C720
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0005634 nucleus
GO:0008622 epsilon DNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hv8, PDBe:6hv8, PDBj:6hv8
PDBsum6hv8
PubMed30498216
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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