Structure of PDB 6hpu Chain A Binding Site BS02

Receptor Information
>6hpu Chain A (length=418) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRMQLSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVA
TASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQR
LVIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTK
GSQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDE
VTRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRLQELPGKVHRFEA
MDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVV
GFEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAM
SIHKSQGMTLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVR
CDPRVLHFYATLRRGRSL
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain6hpu Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hpu Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.
Resolution3.96 Å
Binding residue
(original residue number in PDB)		A230 K234 E307 Q346 R381 G559 M560 R584
Binding residue
(residue number reindexed from 1)		A28 K32 E105 Q144 R179 G357 M358 R382
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
Biological Process
GO:0000723 telomere maintenance
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hpu, PDBe:6hpu, PDBj:6hpu
PDBsum6hpu
PubMed30698796
UniProtQ9H611|PIF1_HUMAN ATP-dependent DNA helicase PIF1 (Gene Name=PIF1)

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