Structure of PDB 6h1v Chain A Binding Site BS02

Receptor Information
>6h1v Chain A (length=1114) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLT
NMHATLVSQENQGISGVDFYFLDEEGGSFKSTVVYDPYFFIACNDESRVN
DVEELVKKYLESCLKSLQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLF
EARKLLRPILQDNANNNVQRNIYNVDAKHLIEDIREYDVPYHVRVSIDKD
IRVGKWYKVTQQGFIEDTRKIAFADPVVMAFAIATTKPPLKFPDSAVDQI
MMISYMIDGEGFLITNREIISEDIEDFEYTPKPEYPGFFTIFNENDEVAL
LQRFFEHIRDVRPTVISTFNGDFFDWPFIHNRSKIHGLDMFDEIGFAPDA
EGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAVTQSKLGYNPIELDPEL
MTPYAFEKPQHLSEYSVSDAVATYYLYMKYVHPFIFSLCTIIPLNPDETL
RKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHV
ESLEAGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVT
NFEEIKNQITQKLLELKENNIRNELPLIYHVDVASMYPNIMTTNRLQPDS
IKAERDCKTCARKLKWAWRGEFFPSKMDEYNMIKRALQNETFPNKKVLTF
DELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVEREAIVCQRENPFYVDT
VKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQLAH
KVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLE
LDTDGIWCILPKSFPETYFFTLENGKKLYLSYPCSMLNYRVHQKFTNHQY
QELKDPLNYIYETHSENTIFFEVDGPYKAMILPSSKEEGKGIKKRYAVFN
EDGSLAELKGFELKRRGELQLIKNFQSDIFKVFLEGDTLEGCYSAVASVC
NRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQKSTSITTARRL
GDFLGEDMVKDKGLQCKYIISSKPFNAPVTERAIPVAIFSADIPIKRSFL
RRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPR
VEHPDWLKRKIATK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6h1v Structural evidence for an essential Fe-S cluster in the catalytic core domain of DNA polymerase ε.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		K510 G511 T512 G513 T514 T552 Y553 V554 G555 R686 S829 G832 M835 R836 K837 K963 K966 K967 R968 R988 T1065 T1103 Y1145 R1149
Binding residue
(residue number reindexed from 1)		K452 G453 T454 G455 T456 T494 Y495 V496 G497 R619 S756 G759 M762 R763 K764 K890 K893 K894 R895 R915 T992 T1030 Y1072 R1076
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
Cellular Component
GO:0008622 epsilon DNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6h1v, PDBe:6h1v, PDBj:6h1v
PDBsum6h1v
PubMed30968138
UniProtP21951|DPOE_YEAST DNA polymerase epsilon catalytic subunit A (Gene Name=POL2)

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