Structure of PDB 6gpg Chain A Binding Site BS02

Receptor Information
>6gpg Chain A (length=651) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPFKPRNYQLELALPAMKGKNTIICAPTGFGKTFVSLLICEHHLKKFPQG
QKGKVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIV
ENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMF
NYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASV
IATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKR
ICKDLNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHL
RKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQ
ELESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKN
WIEGNPKLSFLKPGILTGDHNILIATSVADEGIDIAQCNLVILYEYVGNV
IKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTW
DEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTA
DVRVIEECHYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSH
DWGIHVKYKTFEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPA
E
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gpg Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
Resolution2.894 Å
Binding residue
(original residue number in PDB)		N298 Q299 I300 S325 G326 T347 Q349 E510 Q511 V514 K518 R546 K635 R637 G663 T697 S698 A700 F853 S854
Binding residue
(residue number reindexed from 1)		N60 Q61 I62 S87 G88 T109 Q111 E265 Q266 V269 K273 R301 K390 R392 G418 T426 S427 A429 F582 S583
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6gpg, PDBe:6gpg, PDBj:6gpg
PDBsum6gpg
PubMed30047865
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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