Structure of PDB 6go6 Chain A Binding Site BS02

Receptor Information
>6go6 Chain A (length=359) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYHQYHRSHLADSAHNLRQRSS
TMDVFERSFCILKLDHGRVHSEEGKGWKAIRVDLVMCPYDRRAFALLGWT
GSRQFERDLRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLD
YIEPWERNA
Ligand information
Receptor-Ligand Complex Structure
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PDB6go6 Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		Q152 G186 S187 A190 G218 K220 V221
Binding residue
(residue number reindexed from 1)		Q5 G39 S40 A43 G71 K73 V74
Enzymatic activity
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:6go6, PDBe:6go6, PDBj:6go6
PDBsum6go6
PubMed31138645
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt);
Q9JIW4|DPOLM_MOUSE DNA-directed DNA/RNA polymerase mu (Gene Name=Polm)

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