Structure of PDB 6gml Chain A Binding Site BS02

Receptor Information
>6gml Chain A (length=1407) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNGGCGRYQP
RIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEW
MIVTVLPVPPLSVRPAVRNQDDLTHKLADIVKINNQLRRNEQNGAAAHVI
AEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGN
LMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQ
ELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDG
DIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNL
HLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDV
FLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCI
RTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLV
HISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQ
NTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTG
SSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFK
HRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVK
TAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEF
QNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELE
REFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSD
LHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRR
MAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMT
LNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAER
AKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWLLRV
ELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMND
DDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKA
LQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKC
SFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKC
KYGMEIP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gml Structure of paused transcription complex Pol II-DSIF-NELF.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R67 V264 N272 R334 F431 R460 D499
Binding residue
(residue number reindexed from 1)		R57 V217 N219 R281 F378 R407 D446
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:6gml, PDBe:6gml, PDBj:6gml
PDBsum6gml
PubMed30135580
UniProtI3LJR4

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