Structure of PDB 6gmh Chain A Binding Site BS02

Receptor Information
>6gmh Chain A (length=1441) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNGGCGRYQP
RIRRSGLELYAEWKKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEW
MIVTVLPVPPLSVRPAVVMQRNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRV
RGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNID
RLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHM
CDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDE
MNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTK
RDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAG
SLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQ
DIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARD
KTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPF
GFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDT
AVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQN
ELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRL
PSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLC
SRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPAT
QMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARD
AERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVISPWL
LRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRI
MNDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGE
FKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKA
LERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPL
MKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDA
EKCKYGMEIPGATPAYGAWSPSVGSGMTPGAAGFSPSAASD
Ligand information
>6gmh Chain P (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaccggagagggaacccacu
.....................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gmh Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R67 Q267 F431 R460 D497 D499
Binding residue
(residue number reindexed from 1)		R57 Q220 F381 R410 D447 D449
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6gmh, PDBe:6gmh, PDBj:6gmh
PDBsum6gmh
PubMed30135578
UniProtI3LJR4

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