Structure of PDB 6gkh Chain A Binding Site BS02

Receptor Information
>6gkh Chain A (length=685) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQAS
ESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVV
KSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVY
NNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEK
HILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKL
LEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHL
RKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDKSLKLDETDEF
LMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFT
KTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVI
SKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARA
DESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILE
LQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEK
MHHVNMTPEFKGLYIVRENQTNGEIICKCGQAWGTMMVHKGLDLPCLKIR
NFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gkh Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Resolution4.06 Å
Binding residue
(original residue number in PDB)		G393 T414 Q416 R606 K726 R728 G756 T790 V791 E924 V973 K1001
Binding residue
(residue number reindexed from 1)		G88 T109 Q111 R301 K401 R403 G431 T465 V466 E599 V638 K666
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0038187 pattern recognition receptor activity
GO:0042802 identical protein binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0002376 immune system process
GO:0009615 response to virus
GO:0016925 protein sumoylation
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0039530 MDA-5 signaling pathway
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response
GO:0051259 protein complex oligomerization
GO:0051607 defense response to virus
GO:0060337 type I interferon-mediated signaling pathway
GO:0060760 positive regulation of response to cytokine stimulus
GO:0071360 cellular response to exogenous dsRNA
GO:0098586 cellular response to virus
GO:0140374 antiviral innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gkh, PDBe:6gkh, PDBj:6gkh
PDBsum6gkh
PubMed30449722
UniProtQ8R5F7|IFIH1_MOUSE Interferon-induced helicase C domain-containing protein 1 (Gene Name=Ifih1)

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