Structure of PDB 6gco Chain A Binding Site BS02

Receptor Information
>6gco Chain A (length=409) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVTFKDVAGIEEVKEEVKEIIEYLKDPVKFQPPKGVLLYGEPGVGKTLLA
KAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAPCIIFIDE
IDAVGRHDEREQTLNQLLVEMDGFDTSDGIIVIAATNRPDILDPALLRPG
RFDRQIFIPKPDVRGRYEILKVHARNKKLAKDVDLEFVARATPGFTGADL
ENLLNEAALLAARKITMEEIEEALDRITMMTISPKEKEKIAIHEAGHALM
GLVSDDDDKVHKISIIPRGQLPIEDKHIYDKKDLYNKILVLLGGRAAEEV
FFGKDGITTGAENDLQRATDLAYRMVSMWGMSDKVGPIAITSPDLLREID
EEVKRIITEQYEKAKAIVEEYKEPLKAVVKKLLEKETITCEEFVEVFKLY
GIELKDKCK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6gco Chain A Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6gco Conformational flexibility of pore loop-1 gives insights into substrate translocation by the AAA+protease FtsH.
Resolution3.323 Å
Binding residue
(original residue number in PDB)		H418 H422 R443 D496
Binding residue
(residue number reindexed from 1)		H243 H247 R268 D314
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gco, PDBe:6gco, PDBj:6gco
PDBsum6gco
PubMed30118817
UniProtO67077|FTSH_AQUAE ATP-dependent zinc metalloprotease FtsH (Gene Name=ftsH)

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