Structure of PDB 6g86 Chain A Binding Site BS02

Receptor Information
>6g86 Chain A (length=357) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDNTIEFLRGRVYLGAYDYTPEDTDELVFFTVEDAIFYNSFHLDFGPMNI
GHLYRFAVIFHEILNDPENANKAVVFYSSASTRQRANAACMLCCYMILVQ
AWTPHQVLQPLAQVDPPFMPFRDAGYSNADFEITIQDVVYGVWRAKEKGL
IDLHSFNLESYEKYEHVEFGDFNVLTPDFIAFASPQEDHPKSHLNQPFKS
VLNFFANNNVQLVVRLNSHLYNKKHFEDIGIQHLDLIFEDGTCPDLSIVK
NFVGAAETIIKRGGKIAVHCKAGLGRTGCLIGAHLIYTYGFTANECIGFL
RFIRPGMVVGPQQHWLYLHQNDFREWKYTTRISLKPSEAIGGLYPLISLE
EYRLQKK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6g86 Chain A Residue 407 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6g86 A PxL motif promotes timely cell cycle substrate dephosphorylation by the Cdc14 phosphatase.
Resolution1.74 Å
Binding residue
(original residue number in PDB)		E193 H195 H206 H238
Binding residue
(residue number reindexed from 1)		E187 H189 H193 H225
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Biological Process
External links
PDB RCSB:6g86, PDBe:6g86, PDBj:6g86
PDBsum6g86
PubMed30455435
UniProtQ00684|CDC14_YEAST Tyrosine-protein phosphatase CDC14 (Gene Name=CDC14)

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