Structure of PDB 6g7d Chain A Binding Site BS02

Receptor Information

>6g7d Chain A (length=220) Species: 1122247 (Mycolicibacterium hassiacum DSM 44199)

TDIRDTDALFALADRVTGFMPADEGRTLYETAVRYLGDGVGVEIGTYCGK
STVLLGAAARQTGGVVFTVDHHHGSEEHQPGWEYHDPSLVDPVTGLFDTL
PRLRHTLDEADLYDHVVAVVGKSAVVARGWRTPLRFLFIDGGHTEEAAQR
DFDGWARWVEVGGALVIHDVFPDPKDGGQAPFHIYQRALNTGDFREVNAY
GSMRVLERTSGIAGQPLKLA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 6g7d Chain A Residue 304

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g7d Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides.
• Resolution: 1.35 Å
• Binding residue (original residue number in PDB): D141 H169 D170
• Binding residue (residue number reindexed from 1): D140 H168 D169
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.365: MMP 1-O-methyltransferase.

Gene Ontology

Molecular Function

• GO:0008168 methyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0030206 chondroitin sulfate biosynthetic process
• GO:0032259 methylation
• GO:0071770 DIM/DIP cell wall layer assembly

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:6g7d, PDBe:6g7d, PDBj:6g7d
• PDBsum: 6g7d
• PubMed: 30606802
• UniProt: K5B7F3|MET1_MYCHD MMP 1-O-methyltransferase (Gene Name=meT1)